Nicolau 教授
2016 EAO
演讲独家剖析

即刻负重

即刻负重可
预期性高

健康受损患者

健康受损患
者群体种
植修复成功率

改善骨移植

新生成骨
总量显
著提升

定义成功标准
表现超乎想象

士卓曼联手全球顶尖临床医师一同探索SLActive®种植体在最富挑战性的医学条件和治疗方案下的临床表现,以展示SLActive®表面出色的愈合能力。

通过全新的认知及有效研究数据,您可尽情感受由SLActive®的超凡性能带来的优势,使患者获得最佳的愈合效果。

种植体即刻负重十
年后存活率2
98.2%
存活率
随机多中
心对照研究

化疗伴骨损伤的患
者种植成功率3

100%
成功率

随机临床试验

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即刻负重

成效持久

即刻负重能让患者在植入种植体后立刻进行修复,从而受益
然而,这种治疗方案具有较高的种植失败风险

种植体即刻
负重十年
后存活率2
98.2%
存活率
随机多中心
对照研究
  • 由随机多中心对照研究所得出的全新数据展现了SLActive®种植体即刻负重的非凡表现
  • 实际上,在此严苛条件下,SLActive®种植体10年存活率高达98.2%2
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下载研究概况
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SLActive®用于放化疗患者

预后超乎预期

种植手术中最具挑战的患者群体之一是接受过肿瘤手术、化疗以及放疗患者。此类患者骨质严重受损。

SLActive®在放化疗患者身上的表现

1年跟进调查3
5年跟进调查13,14
随机临床试验:3
  • 102颗种植体,20名患者
  • 口腔癌的术后、放疗和化疗
* 以Buser D.的定义为衡量成功的标准。骨增量后种植体骨结合的长期稳定性: 关于牙体缺损患者的5年预期研究。国际牙周病修复学杂志 2002; 22: 108–17.
更正** ,排除因癌症病故的患者。

5 年随访:最新发表

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Dental Tribune International(世界牙科论坛)新闻动态

观看尼尔森教授的视频采访,详细了解针对放疗患者的咬合重建方面的研究和挑战。

了解 SLActive® 种植牙能如何改善这些患者的生活质量。

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下载研究概况
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绝佳性能

即使在糖尿病患者身上

  • 糖尿病患者伤口愈合能力较低,这会增加种植手术带来的风险
  • 全球60岁及以上的老年人群,其中六分之一患有糖尿病。17

由于一半的2型糖尿病患者并没有得到确诊,临床医生该如何才能从此类患者尤其是老年患者身上规避这类风险?


越来越多的临床证据证实SLActive®在糖尿病患者身上的表现出高度的可预期性:

一项新的临床研究将SLActive®在有糖尿病患者和无糖尿病患者身上进行对比试验。结果验证了SLActive®种植体绝佳的性能表现。

  • 糖尿病患者群体100%的种植成功率
  • 种植患者骨变化情况与健康人群情况相似
  • 尽管已经观察到骨质较差,但所有该研究中涉及的种植体都表现出良好的初期稳定性。

在糖尿病患
者身上的表现19

100%
成功率
病例对照
临床研究
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新研究发现SLActive®具有高度的抗炎潜能:
  • 瑞锆SLActive®表面能够激发早期抗炎细胞应答20
  • SLActive®能够调节糖尿病动物中的过度炎性反应,并改善骨愈合21
关于SLActiveI潜在的抗炎能力的全新数据被发表在International Association for Dental Research, USA:
 
了解更多
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下载SLActive®宣传册
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增强骨组织再生

即使应对存在骨缺损的区域

改善骨移植

骨缺损能极大影响骨结合的可预期性

  • 在最近一项临床前实验中,SLActive® 亲水活性表面与标准士卓曼SLA®疏水表面相比,在八周的时间内,明显表现出更高的植骨成骨性能。

植骨八周后成骨状态

植骨八周后(新骨和植骨材料)的组织病例切片图
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揭晓超凡表面的愈合能力

医师观点

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REFERENCES

1 Straumann SLActive implants compared to Straumann SLA implants. Lang NP, Salvi GE, Huynh-Ba G, Ivanovski S, Donos N, Bosshardt DD. Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clin Oral Implants Res. 2011 Apr;22(4):349-56. doi: 10.1111/j.1600-0501.2011.02172.x.

2 Nicolau P, Guerra F, Reis R, Krafft T, Benz K , Jackowski J 10-year results from a randomized controlled multicenter study with immediately and early loaded SLActive implants in posterior jaws. Presented at 25th Annual Scientific Meeting of the European Association of Osseointegration – 29 Sep – 1 Oct 2016, Paris.

3 Patients  treated with dental implants after surgery and radio-chemotherapy of oral cancer. Heberer S, Kilic S, Hossamo J, Raguse J-D, Nelson K. Rehabilitation of irradiated patients with modified and conventional sandblasted, acid-etched implants: preliminary results of a split-mouth study. Clin. Oral Impl. Res. 22, 2011; 546–551.

4  Yerit, K., Posch, M., Seemann, M., Hainich, S., Dortbudak, O., Turhani, D., Ozyuvaci, H., Watzinger, R. and Ewers, R. (2006) Implant Survival in Mandibles of Irradiated Oral Cancer Patients. Clinical Oral Implants Research, 17, 337-344. http://dx.doi.org/10.1111/j.1600-0501.2005.01160.x

 5 Verdonck, H.W.D., Meijer, G.J., Laurin, T., Nieman, F.H.M., Stoll, C., Riediger, D., Stoelinga, P.J.W. and de Baat, C. (2007) Assessment of Vascularity in Irradiated and Non-Irradiated Maxillary and Mandibular Alveolar Minipig Bone Using Laser Doppler Flowmetry. International Journal of Oral Maxillofacial Implants, 22, 774-778.

6  Hu, W.W., Ward, B.B., Wang, Z. and Krebsbach, P.H. (2010) Bone Regeneration in Defects Compromised by Radiotherapy. Journal of Dental Research, 89, 77-81. http://dx.doi.org/10.1177/0022034509352151

7 Wang, R., Pillai, K. and Jones, P.K. (1998) Dosimetric Measurements of Scatter Radiation from Dental Implants in Stimulated Head and Neck Radiotherapy. International Journal of Oral Maxillofacial Implants, 13, 197-203.

8  Grotz, K.A., Al-Nawas, B., Piepkorn, B., Reichert, T.E., Duschner, H. and Wagner, W.(1999) Micromorphological Findings in Jaw Bone after Radiotherapy. Mund-, Kiefer- und Gesichtschirurgie, 3, 140-145.

9 Chambrone L, Mandia J, Shibli JA, Romito GA, Abrahao M. Dental Implants Installed in Irradiated Jaws: A Systematic Review. Journal of Dental Research. 2013;92(12 Suppl):119S-130S. doi:10.1177/0022034513504947.

10 Shugaa-Addin B, Al-Shamiri H-M, Al-Maweri S, Tarakji B. The effect of radiotherapy on survival of dental implants in head and neck cancer patients. Journal of Clinical and Experimental Dentistry. 2016;8(2):e194-e200. doi:10.4317/jced.52346.

11 Nooh N. Dental implant survival in irradiated oral cancer patients: a systematic review of the literature. Int J Oral Maxillofac Implants. 2013 Sep-Oct;28(5):1233-42. doi: 10.11607/jomi.3045.

12  Dholam KP, Gurav SV. Dental implants in irradiated jaws: A literature review. J Can Res Ther [serial online] 2012 [cited 2016 Aug 17];8:85-93. Available from: http://www.cancerjournal.net/text.asp?2012/8/6/85/92220

13  C. NACK, J.-D. RAGUSE, A. STRICKER , K. NELSON & S. NAHLES. Rehabilitation of irradiated patients with chemically modified and conventional SLA implants: five-year follow-up. Journal of Oral Rehabilitation 2015 42; 57—64

14  Nelson, K., Stricker, A., Raguse, J.-D. and Nahles, S. (2016), Rehabilitation of irradiated patients with chemically modified and conventional SLA implants: a clinical clarification. J Oral Rehabil, 43: 871–872. doi:10.1111/joor.12434

15 Devlin H, Garland H, Sloan P. Healing of tooth extraction sockets in experimental diabetes mellitus. J. of Oral Maxillofac. Surg. 1996; 54:1087-1091.

16  Wang F1, Song YL, Li DH, Li CX, Wang Y, Zhang N, Wang BG. Type 2 diabetes mellitus impairs bone healing of dental implants in GK rats. Diabetes Res Clin Pract. 2010; 88:e7-9.

17 IDF Diabetes Atlas, 7th Edition, 2015 http://www.diabetesatlas.org/

18 US Centers for Disease Control and Prevention. Diabetes 2014 report card. Available from: www.cdc.gov/diabetes/library/reports/congress.html. Accessed September 2015.

19 Machuca G., Cabrera J.J. “A prospective, case-control clinical study of titanium-zirconium allow implants with hydrophilic surface in patients with Type 2 diabetes mellitus” Manuscript submitted.

20 Hotchkiss KM, Ayad NB, Hyzy SL, Boyan BD, Olivares-Navarrete R. Dental implant surface chemistry and energy alter macrophage activation in vitro. Clin. Oral Impl. Res. 00, 2016, 1–10. doi: 10.1111/clr.12814

21  Lee R, Hamlet SM, Ivanovski S. The influence of titanium surface characteristics on macrophage phenotype polarization during osseous healing in type I diabetic rats: A pilot study. Clin Oral Impl Res (accepted 4/8/2016).

22 Straumann (2016). SLActive supports enhanced bone formation in a minipig surgical GBR model with coronal circumferential defects. Unpublished data

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